In short

  • There are multiple drugs that can be used to treat benign prostatic hyperplasia (BPH), or enlarged prostate.
  • Two of the more common drugs used are Finasteride and Dutasteride.
  • There are a few differences between these drugs although they treat similar conditions.

There are multiple drugs that can be used to treat benign prostatic hyperplasia (BPH), or enlarged prostate. Two of the more common drugs used are Finasteride and Dutasteride. There are a few differences between these drugs although they treat similar conditions.

Uses

Finasteride doubles as a treatment for male pattern baldness and for an enlarged prostate. The mechanism for their treatment of BPH is somewhat different. Finasteride is an enzyme blocker, and it actually modifies the makeup of testosterone to deal with these medical problems.

Dutasteride is also an enzyme inhibitor, but instead of modifying testosterone, it blocks the production of dihydrotestosterone, which the prostate requires in order to grow.

Interactions

Finasteride has no known drug interactions. An interaction refers to the way one drug has an effect on the mechanism of another drug, causing it to react in a different manner than it usually does or to create side effects that it would not usually create.

Dutasteride can interact with several different drugs, including some antibiotics, some HIV medications and some blood pressure drugs. There is no evidence that it will make your side effects worse, but it has been shown to slow down the liver’s processes and stays in the blood stream longer when it interacts with these other drugs.

Effectiveness

Both drugs are equally as effective, and you will have to take both of them long term to continue producing the desired effect. In most cases, this treatment is expected to continue for the rest of your life as these drugs control the prostate growth process and keep it at manageable levels.

Side Effects

These two drugs also share many of the same side effects. As far as serious side effects go, they both may increase your chances of developing certain kinds of cancer, specifically prostate cancer.

Milder side effects are shared as well. Both finasteride and dutasteride can cause a decrease in sex drive, and this is a problem that can continue even after you stop taking the drugs. They may also give males some of the characteristics of females over time by causing gynecomastia (enlargement of the breast area). These drugs may cause impotence and problems with ejaculation.

The two drugs are comparable, but there are certain advantages and disadvantages to using each one.

Sources

References

3 sources were selected to match the subject of this article. Link destinations were checked twice when added. This does not mean every statement has been individually source-mapped or clinically approved.

  1. The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis

    PubMed / Clinical Interventions in Aging · HTML · peer-reviewed systematic review and meta-analysis · 2019; PMID 30863034 · Link destination checked 5 September 2026

  2. Relative Efficacy of Minoxidil and the 5-alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients: A Network Meta-analysis

    PubMed / JAMA Dermatology · HTML · peer-reviewed network meta-analysis · 2022; PMID 35107565 · Link destination checked 5 September 2026

  3. MHRA strengthens safety warnings for finasteride and dutasteride

    Medicines and Healthcare products Regulatory Agency · HTML · regulatory safety communication · Published 11 May 2026 · Link destination checked 5 September 2026

Reference links open the cited source pages. If you spot something out of date, tell our content team.

Who wrote this

Written and reviewed by our team

Authored by

Ian Coakley, Content Writer

Content Writer

Ian is Simple Online Pharmacy’s Content Writer; he joined the team in 2021. He has had a varied career path, starting as a science communicator and freelance editor and writer. While Ian has been published in some independent outfits, Simple Online Pharmacy marks his first foray into writing for a corporate entity.

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Medically reviewed by

Karim Nassar, Co-Founder, Pharmacist & Author

Karim Nassar

Co-Founder, Pharmacist & Author

Karim is a registered pharmacist with the General Pharmaceutical Council (GPhC) and was a founding member of Simple Online Healthcare in 2015. With a Master of Pharmacy degree from Strathclyde University, Karim brings a strong foundation in pharmaceutical care and a passion for leveraging digital solutions to improve patient access to healthcare.

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