In short

  • Esomeprazole, also known as Nexium, belongs to a class of drugs known as PPIs and works by reducing the amount of stomach acid produced.
  • Esomeprazole is described as available over the counter in 10mg and 20mg tablets and can also be obtained on prescription.
  • The source lists stopping smoking, reducing alcohol intake, losing weight if overweight, and avoiding eating late or lying down shortly after eating as lifestyle changes that may help reduce acid reflux.

What is Esomeprazole?

Esomeprazole, also known as Nexium, is an effective acid reflux treatment. Esomeprazole belongs to a class of drugs known as PPIs. PPIs work by reducing the amount of stomach acid produced. Acid reflux is caused by stomach acid entering the oesophagus (the food pipe), so drugs like Esomeprazole can help to reduce the chance of this occurring.

Can you buy Esomeprazole over the counter in the UK?

Esomeprazole is available over the counter as 10mg and 20mg tablets, but you can also obtain it on prescription from online pharmacies such as Simple Online Pharmacy. 

Alternative treatments

Other acid reflux treatments are also available over the counter in the UK including:

  • Omeprazole – Omeprazole is another PPI, it works in the same was as Esomeprazole.
  • Antacids – Antacids, such as Rennies, work by neutralising the stomach acid so that if the acid does enter the oesophagus, it won’t cause as much damage.
  • Alginates – Alginates, such as Gaviscon, work by forming a gel-like raft that floats on top of the stomach acid. This helps to stop the stomach acid from entering the oesophagus.
  • Ranitidine – Ranitidine is a type of medication known as an H2-antagonist. It works by blocking the receptors on some of the cells in the stomach. This helps to reduce the amount of acid that the cells produce. It is only available over the counter at a low dose of 75mg.

Prescription acid reflux treatments include other PPIs, such as Lansoprazole and Pantoprazole, as well as other H2-antagonists, including Cimetidine and higher doses of Ranitidine.

Various lifestyle changes can also help to reduce acid reflux. Making these adjustments could remove the need for acid reflux medications altogether. Recommended changes include:

  • Stopping smoking
  • Avoiding alcohol or reducing alcohol intake
  • Losing weight if you are overweight
  • Avoid eating late at night or lying down shortly after eating

Sources

References

2 sources were selected to match the subject of this article. Link destinations were checked twice when added. This does not mean every statement has been individually source-mapped or clinically approved.

  1. About esomeprazole

    NHS · HTML · medicine guidance · Page last reviewed 26 November 2025 · Link destination checked 5 September 2026

  2. Nexium Control 20 mg gastro-resistant tablets (GSL) — Summary of Product Characteristics

    electronic medicines compendium (emc) · HTML · SmPC · Last updated on emc 16 January 2026 · Link destination checked 5 September 2026

Reference links open the cited source pages. If you spot something out of date, tell our content team.

Who wrote this

Written and reviewed by our team

Authored by

Ian Coakley, Content Writer

Content Writer

Ian is Simple Online Pharmacy’s Content Writer; he joined the team in 2021. He has had a varied career path, starting as a science communicator and freelance editor and writer. While Ian has been published in some independent outfits, Simple Online Pharmacy marks his first foray into writing for a corporate entity.

Read Ian’s profile

Medically reviewed by

Karim Nassar, Co-Founder, Pharmacist & Author

Karim Nassar

Co-Founder, Pharmacist & Author

Karim is a registered pharmacist with the General Pharmaceutical Council (GPhC) and was a founding member of Simple Online Healthcare in 2015. With a Master of Pharmacy degree from Strathclyde University, Karim brings a strong foundation in pharmaceutical care and a passion for leveraging digital solutions to improve patient access to healthcare.

Read Karim’s profile

Published

Last medically reviewed

Sources cited

See 2 references

Keep reading

More Acid reflux treatment advice

View all Acid reflux treatment advice